Ontology highlight
ABSTRACT:
SUBMITTER: Richardson SH
PROVIDER: S-EPMC1952157 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Richardson Susan H SH Starborg Tobias T Lu Yinhui Y Humphries Sally M SM Meadows Roger S RS Kadler Karl E KE
Molecular and cellular biology 20070611 17
The ability of tendon to transmit forces from muscle to bone is directly attributable to an extracellular matrix (ECM) containing parallel bundles of collagen fibrils. Although the biosynthesis of collagen is well characterized, how cells deposit the fibrils in regular parallel arrays is not understood. Here we show that cells in the tendon mesenchyme are nearly cylindrical and are aligned side by side and end to end along the proximal-distal axis of the limb. Using three-dimensional reconstruct ...[more]