Ontology highlight
ABSTRACT:
SUBMITTER: Bartolome RA
PROVIDER: S-EPMC1952211 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Bartolomé Rubén A RA Molina-Ortiz Isabel I Samaniego Rafael R Sánchez-Mateos Paloma P Bustelo Xosé R XR Teixidó Joaquin J
Cancer research 20060101 1
Melanoma cells express the chemokine receptor CXCR4, which confers invasive signals on binding to its ligand CXCL12. We show here that knocking down membrane-type matrix metalloproteinase (MT1-MMP) expression translates into a blockade of invasion across reconstituted basement membranes and type I collagen gels in response to CXCL12, which is the result of lack of MMP-2 activation. Interference with MMP-2 expression further confirms its important role during this invasion. Vav proteins are guani ...[more]