Ontology highlight
ABSTRACT:
SUBMITTER: Puig-Basagoiti F
PROVIDER: S-EPMC1952232 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Virology 20061218 1
An adaptive mutation (E249G) within West Nile virus (WNV) NS4B gene was consistently recovered from replicon RNAs in C3H/He mouse cells. The E249G is located at the C-terminal tail of NS4B predicted to be on the cytoplasmic side of the endoplasmic reticulum membrane. The E249G substitution reduced replicon RNA synthesis. Compared with the wild-type NS4B, the E249G mutant protein exhibited a similar efficiency in evasion of interferon-beta response. Recombinant E249G virus exhibited smaller plaqu ...[more]