Ontology highlight
ABSTRACT:
SUBMITTER: She M
PROVIDER: S-EPMC1952686 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20051211 1
Decapping is a key step in both general and nonsense-mediated 5' --> 3' mRNA-decay pathways. Removal of the cap structure is catalyzed by the Dcp1-Dcp2 complex. The crystal structure of a C-terminally truncated Schizosaccharomyces pombe Dcp2p reveals two distinct domains: an all-helical N-terminal domain and a C-terminal domain that is a classic Nudix fold. The C-terminal domain of both Saccharomyces cerevisiae and S. pombe Dcp2p proteins is sufficient for decapping activity, although the N-term ...[more]