IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis.

ABSTRACT:

Background

Recently, a new genetic factor within the interferon regulatory factor 5 (IRF5) gene was demonstrated for systemic lupus erythematosus (SLE) through linkage and association: the rs2004640-T allele. IRF5 is involved in the production of rheumatoid arthritis (RA) cytokines, and SLE already shares with RA one genetic factor within the tyrosine phosphatase PTPN22 gene.

Aim

To test the hypothesis that the SLE IRF5 genetic factor could also be shared with RA.

Patients and methods

100 French Caucasian trio families with RA were genotyped and analysed with the transmission disequilibrium test, the frequency comparison of the transmitted and untransmitted alleles, and the genotype relative risk. 97% power was available to detect at least a trend in favour of a facto

SUBMITTER: Garnier S 

PROVIDER: S-EPMC1954661 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature