Ontology highlight
ABSTRACT:
SUBMITTER: Freedman R
PROVIDER: S-EPMC19557 | biostudies-literature | 1997 Jan
REPOSITORIES: biostudies-literature
Freedman R R Coon H H Myles-Worsley M M Orr-Urtreger A A Olincy A A Davis A A Polymeropoulos M M Holik J J Hopkins J J Hoff M M Rosenthal J J Waldo M C MC Reimherr F F Wender P P Yaw J J Young D A DA Breese C R CR Adams C C Patterson D D Adler L E LE Kruglyak L L Leonard S S Byerley W W
Proceedings of the National Academy of Sciences of the United States of America 19970101 2
Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in the normal inhibition of the P50 auditory-evoked response to the second of paired stimuli, is associated with attentional disturbances in schizophrenia. Decreased P50 inhibition occurs not only in most schizophrenics, but also in many of their nonschizophrenic relatives, in a distribution consistent with inherited ...[more]