Ontology highlight
ABSTRACT:
SUBMITTER: Oldberg A
PROVIDER: S-EPMC1955775 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Oldberg Ake A Kalamajski Sebastian S Salnikov Alexei V AV Stuhr Linda L Mörgelin Matthias M Reed Rolf K RK Heldin Nils-Erik NE Rubin Kristofer K
Proceedings of the National Academy of Sciences of the United States of America 20070822 35
Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based treatment of solid malignancies. Tumor stroma is characterized by distorted blood vessels and activated connective tissue cells producing a collagen-rich matrix, which is accompanied by elevated interstitial fluid pressure (IFP), indicating a transport barrier between tumor tissue and blood. Here, we show that the collagen-binding proteogly ...[more]