Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone.
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ABSTRACT:
SUBMITTER: Hirbe AC
PROVIDER: S-EPMC1955795 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Publications
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone.
Hirbe Angela C AC Rubin Jessica J Uluçkan Ozge O Morgan Elizabeth A EA Eagleton Mark C MC Prior Julie L JL Piwnica-Worms David D Weilbaecher Katherine N KN
Proceedings of the National Academy of Sciences of the United States of America 20070822 35
CXCR4 regulates hematopoietic and tumor cell homing to bone, but its role during osteoclast (OC) development is unknown. We investigated the role of CXCR4 in osteoclastogenesis and in a model of bone metastasis. Compared with controls, mice reconstituted with CXCR4 null hematopoietic cells exhibited elevated markers of bone resorption, increased OC perimeter along bone, and increased bone loss. CXCR4-/- OCs demonstrated accelerated differentiation and enhanced bone resorption in vitro. Furthermo ...[more]
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