Ontology highlight
ABSTRACT:
SUBMITTER: Wolf RM
PROVIDER: S-EPMC196001 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Wolf Rebecca M RM Draghi Nicole N Liang Xiquan X Dai Chengkai C Uhrbom Lene L Eklöf Charlotta C Westermark Bengt B Holland Eric C EC Resh Marilyn D MD
Genes & development 20030201 4
p190RhoGAP and Rho are key regulators of oligodendrocyte differentiation. The gene encoding p190RhoGAP is located at 19q13.3 of the human chromosome, a locus that is deleted in 50%-80% of oligodendrogliomas. Here we provide evidence that p190RhoGAP may suppress gliomagenesis by inducing a differentiated glial phenotype. Using a cell culture model of autocrine loop PDGF stimulation, we show that reduced Rho activity via p190RhoGAP overexpression or Rho kinase inhibition induced cellular process e ...[more]