Ontology highlight
ABSTRACT:
SUBMITTER: Raya A
PROVIDER: S-EPMC196060 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Genes & development 20030502 10
Left-sided expression of Nodal in the lateral plate mesoderm is a conserved feature necessary for the establishment of normal left-right asymmetry during vertebrate embryogenesis. By using gain- and loss-of-function experiments in zebrafish and mouse, we show that the activity of the Notch pathway is necessary and sufficient for Nodal expression around the node, and for proper left-right determination. We identify Notch-responsive elements in the Nodal promoter, and unveil a direct relationship ...[more]