Ontology highlight
ABSTRACT:
SUBMITTER: Soshnikova N
PROVIDER: S-EPMC196251 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Soshnikova Natalia N Zechner Dietmar D Huelsken Joerg J Mishina Yuji Y Behringer Richard R RR Taketo Makoto M MM Crenshaw E Bryan EB Birchmeier Walter W
Genes & development 20030801 16
By conditional gene ablation in mice, we found that beta-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that beta-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled ...[more]