Ontology highlight
ABSTRACT:
SUBMITTER: Lynn FC
PROVIDER: S-EPMC1965542 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Lynn F C FC Smith S B SB Wilson M E ME Yang K Y KY Nekrep N N German M S MS
Proceedings of the National Academy of Sciences of the United States of America 20070611 25
During pancreas development, both the exocrine and endocrine lineages differentiate from a common pool of progenitor cells with similarities to mature pancreatic duct cells. A small set of transcription factors, including Tcf2, Onecut1, and Foxa2, has been identified in these pancreatic progenitor cells. The Sry/HMG box transcription factor Sox9 is also expressed in the early pancreatic epithelium and is required for normal pancreatic exocrine and endocrine development in humans. In this study, ...[more]