Ontology highlight
ABSTRACT:
SUBMITTER: Adams CM
PROVIDER: S-EPMC196858 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Adams Christopher M CM Goldstein Joseph L JL Brown Michael S MS
Proceedings of the National Academy of Sciences of the United States of America 20030908 19
Sterols mediate feedback inhibition of the sterol regulatory element-binding protein (SREBP) pathway by preventing movement of the SREBP cleavage-activating protein (SCAP)/SREBP complex from endoplasmic reticulum (ER) to Golgi, where proteolytic cleavage of SREBPs releases the transcription factor domain that activates genes for lipid biosynthesis. Our laboratory previously used a trypsin cleavage assay to show that the conformation of SCAP is altered in vitro by addition of cholesterol to ER me ...[more]