Ontology highlight
ABSTRACT:
SUBMITTER: Belnap DM
PROVIDER: S-EPMC196897 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Belnap D M DM Watts N R NR Conway J F JF Cheng N N Stahl S J SJ Wingfield P T PT Steven A C AC
Proceedings of the National Academy of Sciences of the United States of America 20030903 19
Core antigen (cAg), the viral capsid, is one of the three major clinical antigens of hepatitis B virus. cAg has been described as presenting either one or two conformational epitopes involving the "immunodominant loop." We have investigated cAg antigenicity by cryo-electron microscopy at approximately 11-A resolution of capsids labeled with monoclonal Fabs, combined with molecular modeling, and describe here two conformational epitopes. Both Fabs bind to the dimeric external spikes, and each epi ...[more]