Ontology highlight
ABSTRACT:
SUBMITTER: Rosen H
PROVIDER: S-EPMC196901 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Rosen Hugh H Alfonso Christopher C Surh Charles D CD McHeyzer-Williams Michael G MG
Proceedings of the National Academy of Sciences of the United States of America 20030903 19
Only a small number of T cells generated in the thymus each day are selected to replenish the peripheral T cell pool. Much is known about thymic selection; however, little is known of the mechanisms regulating medullary maturation and the release of mature T cells into the blood. Here we demonstrate a rapid acceleration of medullary thymocyte phenotypic maturation through loss of CD69 induced by sphingosine 1-phosphate (S1P) receptor agonist. Low nanomolar agonist concentrations selectively indu ...[more]