Ontology highlight
ABSTRACT:
SUBMITTER: Conant K
PROVIDER: S-EPMC19704 | biostudies-literature | 1998 Mar
REPOSITORIES: biostudies-literature
Conant K K Garzino-Demo A A Nath A A McArthur J C JC Halliday W W Power C C Gallo R C RC Major E O EO
Proceedings of the National Academy of Sciences of the United States of America 19980301 6
Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. In the present study, we show that the HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte ...[more]