Ontology highlight
ABSTRACT:
SUBMITTER: Millican EA
PROVIDER: S-EPMC1975838 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Millican Eric A EA Lenzini Petra A PA Milligan Paul E PE Grosso Leonard L Eby Charles C Deych Elena E Grice Gloria G Clohisy John C JC Barrack Robert L RL Burnett R Stephen J RS Voora Deepak D Gatchel Susan S Tiemeier Amy A Gage Brian F BF
Blood 20070326 5
High variability in drug response and a narrow therapeutic index complicate warfarin therapy initiation. No existing algorithm provides recommendations on refining the initial warfarin dose based on genetic variables, clinical data, and international normalized ratio (INR) values. Our goal was to develop such an algorithm. We studied 92 patients undergoing primary or revision total hip or knee replacement. From each patient we collected a blood sample, clinical variables, current medications, an ...[more]