Ontology highlight
ABSTRACT:
SUBMITTER: Liao JC
PROVIDER: S-EPMC1976276 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Liao Jack C F JC Gregor Polly P Wolchok Jedd D JD Orlandi Francesca F Craft Diane D Leung Carrie C Houghton Alan N AN Bergman Philip J PJ
Cancer immunity 20060421
Antitumor immune responses can be elicited in preclinical mouse melanoma models using plasmid DNA vaccines encoding xenogeneic melanosomal differentiation antigens. We previously reported on a phase I clinical trial of human tyrosinase (huTyr) DNA vaccination of 9 dogs with advanced malignant melanoma (World Health Organization stages II-IV), in which we demonstrated the safety of the treatment and the prolongation of the expected survival time (ST) of subjects as compared to historical, stage-m ...[more]