A predicted operon map for Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: Roback P
PROVIDER: S-EPMC1976454 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
A predicted operon map for Mycobacterium tuberculosis.
Roback P P Beard J J Baumann D D Gille C C Henry K K Krohn S S Wiste H H Voskuil M I MI Rainville C C Rutherford R R
Nucleic acids research 20070725 15
The prediction of operons in Mycobacterium tuberculosis (MTB) is a first step toward understanding the regulatory network of this pathogen. Here we apply a statistical model using logistic regression to predict operons in MTB. As predictors, our model incorporates intergenic distance and the correlation of gene expression calculated for adjacent gene pairs from over 474 microarray experiments with MTB RNA. We validate our findings with known examples from the literature and experimentation. From ...[more]
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