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Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis.

ABSTRACT: Two molecular structures of the copper(II) complex, Cu(H(2)TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(II) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(II) complexes formed. The single crystal X-ray structures of two copper(II) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.

SUBMITTER: Silversides JD

PROVIDER: S-EPMC1978068 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis.

Silversides Jon D JD Allan Cheryll C CC Archibald Stephen J SJ

Dalton transactions (Cambridge, England : 2003) 20070201 9

Two molecular structures of the copper(II) complex, Cu(H(2)TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(II) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid ...[more]

PMID: 17308678

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Dataset Information

Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis.

Publications

Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis.

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