Rewired ERK-JNK signaling pathways in melanoma.
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ABSTRACT:
SUBMITTER: Lopez-Bergami P
PROVIDER: S-EPMC1978100 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Rewired ERK-JNK signaling pathways in melanoma.
Lopez-Bergami Pablo P Huang Conway C Goydos James S JS Yip Dana D Bar-Eli Menashe M Herlyn Meenhard M Smalley Keiran S M KS Mahale Alka A Eroshkin Alexey A Aaronson Stuart S Ronai Ze'ev Z
Cancer cell 20070501 5
Constitutive activation of MEK-ERK signaling is often found in melanomas. Here, we identify a mechanism that links ERK with JNK signaling in human melanoma. Constitutively active ERK increases c-Jun transcription and stability, which are mediated by CREB and GSK3, respectively. Subsequently, c-Jun increases transcription of target genes, including RACK1, an adaptor protein that enables PKC to phosphorylate and enhance JNK activity, enforcing a feed-forward mechanism of the JNK-Jun pathway. Activ ...[more]
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