Ontology highlight
ABSTRACT:
SUBMITTER: Wilson MS
PROVIDER: S-EPMC1978425 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Wilson Mark S MS Elnekave Eldad E Mentink-Kane Margaret M MM Hodges Marcus G MG Pesce John T JT Ramalingam Thirumalai R TR Thompson Robert W RW Kamanaka Masahito M Flavell Richard A RA Keane-Myers Andrea A Cheever Allen W AW Wynn Thomas A TA
The Journal of clinical investigation 20071001 10
Development of persistent Th2 responses in asthma and chronic helminth infections are a major health concern. IL-10 has been identified as a critical regulator of Th2 immunity, but mechanisms for controlling Th2 effector function remain unclear. IL-10 also has paradoxical effects on Th2-associated pathology, with IL-10 deficiency resulting in increased Th2-driven inflammation but also reduced airway hyperreactivity (AHR), mucus hypersecretion, and fibrosis. We demonstrate that increased IL-13 re ...[more]