A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice.

ABSTRACT: A spontaneous variant of the mouse class I major histocompatibility complex D(b) gene, designated D(bm28), is characterized. This mutation consists of a cluster of nucleotide substitutions in exon 3 that resembles the product of a classical gene conversion event in that the substituted nucleotides appear to be templated. However, D(bm28) is distinctive, because no single donor gene containing the nucleotide sequence of the mutation exists in the genome of the parent strain. The mutation is consistent with the expected result of an interaction of two donor genes at the target locus during a single recombination event. While no known genetic mechanism gives rise to this class of mutation, we have established that 10 percent of spontaneous class I mutations in the mouse major histocompatibili

SUBMITTER: Yun TJ 

PROVIDER: S-EPMC19800 | biostudies-literature | 1997 Feb

REPOSITORIES: biostudies-literature