Ontology highlight
ABSTRACT:
SUBMITTER: Wilson CL
PROVIDER: S-EPMC19803 | biostudies-literature | 1997 Feb
REPOSITORIES: biostudies-literature
Wilson C L CL Heppner K J KJ Labosky P A PA Hogan B L BL Matrisian L M LM
Proceedings of the National Academy of Sciences of the United States of America 19970201 4
Matrix metalloproteinases (MMPs) classically have been implicated in basement membrane destruction associated with late-stage tumor cell invasion and metastasis. However, recent studies have demonstrated that one MMP family member, matrilysin, is expressed in a high percentage of early-stage human colorectal tumors. We analyzed matrilysin expression in benign intestinal tumors from mice heterozygous for the ApcMin allele (Min/+) and found that the mRNA was induced in the majority (88%) of these ...[more]