Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Anoveros J
PROVIDER: S-EPMC19813 | biostudies-literature | 1997 Feb
REPOSITORIES: biostudies-literature
García-Añoveros J J Derfler B B Neville-Golden J J Hyman B T BT Corey D P DP
Proceedings of the National Academy of Sciences of the United States of America 19970201 4
The recently defined DEG/ENaC superfamily of sodium channels includes subunits of the amiloride-sensitive epithelial sodium channel (ENaC) of vertebrate colon, lung, kidney, and tongue, a molluscan FMRFamide-gated channel (FaNaC), and the nematode degenerins, which are suspected mechanosensory channels. We have identified two new members of this superfamily (BNaC1 and BNaC2) in a human brain cDNA library. Phylogenetic analysis indicates they are equally divergent from all other members of the DE ...[more]