Ontology highlight
ABSTRACT:
SUBMITTER: Adriani M
PROVIDER: S-EPMC1986664 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Adriani Marsilio M Aoki Joseph J Horai Reiko R Thornton Angela M AM Konno Akihiro A Kirby Martha M Anderson Stacie M SM Siegel Richard M RM Candotti Fabio F Schwartzberg Pamela L PL
Clinical immunology (Orlando, Fla.) 20070518 1
Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency characterized by the contradictory coexistence of impaired T-cell function and exaggerated T-cell-mediated pathology, including autoimmunity and eczema. WAS protein (WASp)-deficient mice are also immunodeficient and can develop autoimmune disease. Since defects in regulatory T-cells (Treg) are associated with autoimmunity, we examined the presence and function of these cells in WAS patients and WASp-deficient mice. We found that CD4(+) ...[more]