Ontology highlight
ABSTRACT:
SUBMITTER: Abdelmohsen K
PROVIDER: S-EPMC1986740 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Abdelmohsen Kotb K Pullmann Rudolf R Lal Ashish A Kim Hyeon Ho HH Galban Stefanie S Yang Xiaoling X Blethrow Justin D JD Walker Mark M Shubert Jonathan J Gillespie David A DA Furneaux Henry H Gorospe Myriam M
Molecular cell 20070201 4
The RNA binding protein HuR regulates the stability of many target mRNAs. Here, we report that HuR associated with the 3' untranslated region of the mRNA encoding the longevity and stress-response protein SIRT1, stabilized the SIRT1 mRNA, and increased SIRT1 expression levels. Unexpectedly, oxidative stress triggered the dissociation of the [HuR-SIRT1 mRNA] complex, in turn promoting SIRT1 mRNA decay, reducing SIRT1 abundance, and lowering cell survival. The cell cycle checkpoint kinase Chk2 was ...[more]