Ontology highlight
ABSTRACT:
SUBMITTER: Miller JS
PROVIDER: S-EPMC1988949 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Miller Jeffrey S JS Weisdorf Daniel J DJ Burns Linda J LJ Slungaard Arne A Wagner John E JE Verneris Michael R MR Cooley Sarah S Wangen Rosanna R Fautsch Susan K SK Nicklow Roby R Defor Todd T Blazar Bruce R BR
Blood 20070619 7
Donor lymphocyte infusions (DLIs) can produce lasting remissions in patients with relapsed chronic myeloid leukemia (CML), but are less effective in non-CML diseases. We hypothesized that lymphodepletion, achieved with cyclophosphamide (Cy) and fludarabine (Flu), would promote in vivo expansion of the infused lymphocytes enhancing their immunologic effects. Fifteen patients with relapsed non-CML disease who received Cy/Flu/DLI were compared with 63 controls who received DLI without chemotherapy. ...[more]