Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC1991276 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Lu Miao M Lin Su-Chang SC Huang Yihua Y Kang Young Jun YJ Rich Rebecca R Lo Yu-Chih YC Myszka David D Han Jiahuai J Wu Hao H
Molecular cell 20070601 5
In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-kappaB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-kappaB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-kappaB pathway. We report the crystal structures of BIR1, TAB1, and the ...[more]