Ontology highlight
ABSTRACT:
SUBMITTER: Lee MK
PROVIDER: S-EPMC1994119 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Lee Matt K MK Pardoux Cécile C Hall Marie C MC Lee Pierre S PS Warburton David D Qing Jing J Smith Susan M SM Derynck Rik R
The EMBO journal 20070802 17
Erk1/Erk2 MAP kinases are key regulators of cell behaviour and their activation is generally associated with tyrosine kinase signalling. However, TGF-beta stimulation also activates Erk MAP kinases through an undefined mechanism, albeit to a much lower level than receptor tyrosine kinase stimulation. We report that upon TGF-beta stimulation, the activated TGF-beta type I receptor (TbetaRI) recruits and directly phosphorylates ShcA proteins on tyrosine and serine. This dual phosphorylation result ...[more]