Ontology highlight
ABSTRACT:
SUBMITTER: Oottamasathien S
PROVIDER: S-EPMC1994155 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Oottamasathien Siam S Wang YongQing Y Williams Karin K Franco Omar E OE Wills Marcia L ML Thomas John C JC Saba Katrina K Sharif-Afshar Ali-Reza AR Makari John H JH Bhowmick Neil A NA DeMarco Romano T RT Hipkens Susan S Magnuson Mark M Brock John W JW Hayward Simon W SW Pope John C JC Matusik Robert J RJ
Developmental biology 20070112 2
Manipulatable models of bladder development which interrogate specific pathways are badly needed. Such models will allow a systematic investigation of the multitude of pathologies which result from developmental defects of the urinary bladder. In the present communication, we describe a model in which mouse embryonic stem (ES) cells are directed to differentiate to form bladder tissue by specific interactions with fetal bladder mesenchyme. This model allows us to visualize the various stages in ...[more]