Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker.
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ABSTRACT:
SUBMITTER: Sulzbacher I
PROVIDER: S-EPMC1995767 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker.
Sulzbacher Irene I Birner Peter P Toma Cyril C Wick Nikolaus N Mazal Peter R PR
Journal of clinical pathology 20061003 7
<h4>Aims</h4>To examine the prognostic relevance of c-kit expression in human osteosarcomas and to evaluate the mutation status in exon 9 and exon 11 of the c-kit gene.<h4>Methods</h4>c-kit expression was examined in 100 human osteosarcomas by immunohistochemistry using paraffin embedded tumour tissues, and capillary sequencing of genomic DNA was performed to search for mutations in exons 9 and 11 of the c-kit gene.<h4>Results</h4>20 osteosarcomas showed c-kit expression ranging from 5% to 90% ( ...[more]
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