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Resting-state networks in the infant brain.


ABSTRACT: In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map patterns of resting-state activity in infants during sleep. We found five unique resting-states networks in the infant brain that encompassed the primary visual cortex, bilateral sensorimotor areas, bilateral auditory cortex, a network including the precuneus area, lateral parietal cortex, and the cerebellum as well as an anterior network that incorporated the medial and dorsolateral prefrontal cortex. These results suggest that resting-state networks driven by spontaneous signal fluctuations are present already in the infant brain. The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed.

SUBMITTER: Fransson P 

PROVIDER: S-EPMC2000516 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature

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Resting-state networks in the infant brain.

Fransson Peter P   Skiöld Beatrice B   Horsch Sandra S   Nordell Anders A   Blennow Mats M   Lagercrantz Hugo H   Aden Ulrika U  

Proceedings of the National Academy of Sciences of the United States of America 20070918 39


In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map patterns of resting-state activity in infants during sleep. We found five unique resting-states networks in the infant brain that encompassed the pr  ...[more]

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