Ontology highlight
ABSTRACT:
SUBMITTER: Buttner EA
PROVIDER: S-EPMC2000799 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Buttner Edgar A EA Gil-Krzewska Aleksandra J AJ Rajpurohit Anandita K AK Hunter Craig P CP
Developmental biology 20070224 2
Deletion of the lissencephaly disease gene LIS-1 in humans causes an extreme disorganization of the brain associated with significant reduction in cortical neurons. Here we show that deletion or RNA interference (RNAi) of Caenorhabditis elegans lis-1 results in a reduction in germline nuclei and causes a variety of cellular, developmental, and neurological defects throughout development. Our analysis of the germline defects suggests that the reduction in nuclei number stems from dysfunctional mi ...[more]