Ontology highlight
ABSTRACT:
SUBMITTER: Shin Y
PROVIDER: S-EPMC2000856 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Tetrahedron 20070801 35
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a number of other isomers and analogs are reported. Three main fragments-top, middle and bottom-were first assembled and then joined by olefination or anionic addition reactions. After appending the two dienes at either end of the molecule, macrolactonization and deprotection completed the syntheses. The work proves both the relative and absolute configurations of (-)-dictyostatin. The compounds wer ...[more]