High levels of subgenomic HCV plasma RNA in immunosilent infections.
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ABSTRACT:
SUBMITTER: Bernardin F
PROVIDER: S-EPMC2001282 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
High levels of subgenomic HCV plasma RNA in immunosilent infections.
Bernardin Flavien F Stramer Susan L SL Rehermann Barbara B Page-Shafer Kimberly K Cooper Stewart S Bangsberg David R DR Hahn Judith J Tobler Leslie L Busch Michael M Delwart Eric E
Virology 20070509 2
A genetic analysis of hepatitis C virus (HCV) in rare blood donors who remained HCV seronegative despite long-term high-level viremia revealed the chronic presence of HCV genomes with large in frame deletions in their structural genes. Full-length HCV genomes were only detected as minority variants. In one immunodeficiency virus (HIV) co-infected donor the truncated HCV genome transiently decreased in frequency concomitant with delayed seroconversion and re-emerged following partial seroreversio ...[more]
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