Ontology highlight
ABSTRACT:
SUBMITTER: Groen AK
PROVIDER: S-EPMC200929 | biostudies-literature | 2001 Sep
REPOSITORIES: biostudies-literature
Groen A K AK Bloks V W VW Bandsma R H RH Ottenhoff R R Chimini G G Kuipers F F
The Journal of clinical investigation 20010901 6
The ABC transporter ABCA1 regulates HDL levels and is considered to control the first step of reverse cholesterol transport from the periphery to the liver. To test this concept, we studied the effect of ABCA1 deficiency on hepatic metabolism and hepatobiliary flux of cholesterol in mice. Hepatic lipid contents and biliary secretion rates were determined in Abca1(-/-), Abca1(+/-), and Abca1(+/+) mice with a DBA background that were fed either standard chow or a high-fat, high-cholesterol diet. H ...[more]