Dataset Information

Squid Pax-6 and eye development.

ABSTRACT: Pax-6 in vertebrates and its homolog eyeless in Drosophila are known to be essential for eye development. Here we investigate the role of Pax-6 in eye development in another major systematic group, molluscs. We demonstrate that alternatively spliced RNAs derived from a single Pax-6 gene in the squid (Loligo opalescens) are expressed in the embryonic eye, olfactory organ, brain, and arms. Despite significant sequence differences between squid Pax-6 and Drosophila eyeless in the region outside the paired- and homeodomains, squid Pax-6 is able to induce the formation of ectopic eyes in Drosophila. Our results support the idea that Pax-6 related genes are necessary for eye and olfactory system formation throughout the animal kingdom.

SUBMITTER: Tomarev SI

PROVIDER: S-EPMC20103 | biostudies-literature | 1997 Mar

REPOSITORIES: biostudies-literature

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Squid Pax-6 and eye development.

Tomarev S I SI Callaerts P P Kos L L Zinovieva R R Halder G G Gehring W W Piatigorsky J J

Proceedings of the National Academy of Sciences of the United States of America 19970301 6

Pax-6 in vertebrates and its homolog eyeless in Drosophila are known to be essential for eye development. Here we investigate the role of Pax-6 in eye development in another major systematic group, molluscs. We demonstrate that alternatively spliced RNAs derived from a single Pax-6 gene in the squid (Loligo opalescens) are expressed in the embryonic eye, olfactory organ, brain, and arms. Despite significant sequence differences between squid Pax-6 and Drosophila eyeless in the region outside the ...[more]

PMID: 9122210

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Dataset Information

Squid Pax-6 and eye development.

Publications

Squid Pax-6 and eye development.

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