Ontology highlight
ABSTRACT:
SUBMITTER: Simone E
PROVIDER: S-EPMC20120 | biostudies-literature | 1997 Mar
REPOSITORIES: biostudies-literature
Simone E E Daniel D D Schloot N N Gottlieb P P Babu S S Kawasaki E E Wegmann D D Eisenbarth G S GS
Proceedings of the National Academy of Sciences of the United States of America 19970301 6
Restricted use of T cell receptor (TCR) gene segments is characteristic of several induced autoimmune disease models. TCR sequences have previously been unavailable for pathogenic T cells which react with a defined autoantigen in a spontaneous autoimmune disease. The majority of T cell clones, derived from islets of NOD mice which spontaneously develop type I diabetes, react with insulin peptide B-(9-23). We have sequenced the alpha and beta chains of TCRs from these B-(9-23)-reactive T cell clo ...[more]