Ontology highlight
ABSTRACT:
SUBMITTER: Babity JM
PROVIDER: S-EPMC20141 | biostudies-literature | 1997 Mar
REPOSITORIES: biostudies-literature
Babity J M JM Armstrong J N JN Plumier J C JC Currie R W RW Robertson H A HA
Proceedings of the National Academy of Sciences of the United States of America 19970301 6
Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of motor convulsions and the degeneration of neurons in the hippocampus and piriform cortex. Differential display PCR was used to identify mRNAs that are differentially expressed between degenerating and nondegenerating tissues in the brain after kainic acid-induced seizure activity. A novel cDNA fra ...[more]