Ontology highlight
ABSTRACT:
SUBMITTER: Shultzaberger RK
PROVIDER: S-EPMC2018646 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Shultzaberger Ryan K RK Roberts Lindsey R LR Lyakhov Ilya G IG Sidorov Igor A IA Stephen Andrew G AG Fisher Robert J RJ Schneider Thomas D TD
Nucleic acids research 20070707 16
Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics appear to be inaccessible from sequence information since the relative contributions of the on- and off-rates to the binding constant, and hence the free energy, are unknown. However, the on-rate could be independent of the sequence since a protein is likely to bind once it is near a site. To test this, ...[more]