Ontology highlight
ABSTRACT:
SUBMITTER: Knollmann BC
PROVIDER: S-EPMC2025686 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Knollmann Bjorn C BC Sirenko Syevda S Rong Qi Q Katchman Alexander N AN Casimiro Mathew M Pfeifer Karl K Ebert Steven N SN
Biochemical and biophysical research communications 20070615 1
It has been suggested that Kcne1 subunits are required for adrenergic regulation of Kcnq1 potassium channels. However, in adult mouse hearts, which do not express Kcne1, loss of Kcnq1 causes a Long QT phenotype during adrenergic challenge, raising the possibility that native Kcnq1 currents exist and are adrenergically regulated even in absence of Kcne1. Here, we used immunoblotting and immunohistochemical staining to show that Kcnq1 protein is present in adult mouse hearts. Voltage-clamp experim ...[more]