Ontology highlight
ABSTRACT:
SUBMITTER: Marenda DR
PROVIDER: S-EPMC2032010 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Marenda Daniel R DR Vrailas Alysia D AD Rodrigues Aloma B AB Cook Summer S Powers Maureen A MA Lorenzen James A JA Perkins Lizabeth A LA Moses Kevin K
Development (Cambridge, England) 20051124 1
Mitogen-activated protein kinases (MAPKs) phosphorylate target proteins in both the cytoplasm and nucleus, and a strong correlation exists between the subcellular localization of MAPK and resulting cellular responses. It was thought that MAPK phosphorylation was always followed by rapid nuclear translocation. However, we and others have found that MAPK phosphorylation is not always sufficient for nuclear translocation in vivo. In the developing Drosophila wing, MAPK-mediated signaling is require ...[more]