Ontology highlight
ABSTRACT:
SUBMITTER: Nouspikel T
PROVIDER: S-EPMC20331 | biostudies-literature | 1997 Apr
REPOSITORIES: biostudies-literature
Nouspikel T T Lalle P P Leadon S A SA Cooper P K PK Clarkson S G SG
Proceedings of the National Academy of Sciences of the United States of America 19970401 7
Xeroderma pigmentosum (XP) patients have defects in nucleotide excision repair (NER), the versatile repair pathway that removes UV-induced damage and other bulky DNA adducts. Patients with Cockayne syndrome (CS), another rare sun-sensitive disorder, are specifically defective in the preferential removal of damage from the transcribed strand of active genes, a process known as transcription-coupled repair. These two disorders are usually clinically and genetically distinct, but complementation an ...[more]