Ontology highlight
ABSTRACT:
SUBMITTER: MacDiarmid CW
PROVIDER: S-EPMC203372 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
MacDiarmid C W CW Gaither L A LA Eide D D
The EMBO journal 20000601 12
All cells regulate their intracellular zinc levels. In yeast, zinc uptake is mediated by Zrt1p and Zrt2p, which belong to the ZIP family of metal transporters. Under zinc limitation, ZRT1 and ZRT2 transcription is induced by the Zap1p transcriptional activator. We describe here a new component of zinc homeostasis, vacuolar zinc storage, that is also regulated by Zap1p. Zinc-replete cells accumulate zinc in the vacuole via the Zrc1p and Cot1p transporters. Our results indicate that another zinc t ...[more]