Ontology highlight
ABSTRACT:
SUBMITTER: Chapagain ML
PROVIDER: S-EPMC2034208 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Chapagain Moti L ML Verma Saguna S Mercier Frederic F Yanagihara Richard R Nerurkar Vivek R VR
Virology 20070330 1
Although human polyomavirus JC (JCV) is known to cause progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals, the mechanism by which JCV crosses the blood-brain barrier (BBB) remains unclear. To test our hypothesis that cell-free JCV gains entry into the brain by infecting endothelial cells, we inoculated human brain microvascular endothelial (HBMVE) cells with 50 HAU (1.33+/-0.27 x 10(7) genome copies) of JCV(Mad1) and analyzed the expression of early and late viral ...[more]