Ontology highlight
ABSTRACT:
SUBMITTER: Wu JQ
PROVIDER: S-EPMC2034268 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Wu Judy Qiju JQ Hansen David V DV Guo Yanxiang Y Wang Michael Zhuo MZ Tang Wanli W Freel Christopher D CD Tung Jeffrey J JJ Jackson Peter K PK Kornbluth Sally S
Proceedings of the National Academy of Sciences of the United States of America 20070919 42
Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component of CSF, acts in part by promoting the Rsk-mediated phosphorylation of the APC inhibitor Emi2/Erp1. We report here that Rsk phosphorylation of Emi2 promotes its interaction with the protein phosphatase PP2A. Emi2 residues adjacent to the Rsk phosphorylation site were important fo ...[more]