HotPatch: a statistical approach to finding biologically relevant features on protein surfaces.

ABSTRACT: We describe a fully automated algorithm for finding functional sites on protein structures. Our method finds surface patches of unusual physicochemical properties on protein structures, and estimates the patches' probability of overlapping functional sites. Other methods for predicting the locations of specific types of functional sites exist, but in previous analyses, it has been difficult to compare methods when they are applied to different types of sites. Thus, we introduce a new statistical framework that enables rigorous comparisons of the usefulness of different physicochemical properties for predicting virtually any kind of functional site. The program's statistical models were trained for 11 individual properties (electrostatics, concavity, hydrophobicity, etc.) and for 15 neural

SUBMITTER: Pettit FK 

PROVIDER: S-EPMC2034327 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature