Ontology highlight
ABSTRACT:
SUBMITTER: Eimer S
PROVIDER: S-EPMC2034668 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
The EMBO journal 20070913 20
Nicotinic acetylcholine receptors (AChRs) are pentameric ligand-gated ion channels that mediate fast synaptic transmission at the neuromuscular junction (NMJ). After assembly in the endoplasmic reticulum (ER), AChRs must be transported to the plasma membrane through the secretory apparatus. Little is known about specific molecules that mediate this transport. Here we identify a gene that is required for subtype-specific trafficking of assembled nicotinic AChRs in Caenorhabditis elegans. unc-50 e ...[more]