Dataset Information

Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.

ABSTRACT:

Objective

To evaluate the risk of chronic traumatic brain injury from amateur boxing.

Setting

Secondary research performed by combination of sport physicians and clinical academics. DESIGN, DATA SOURCES, AND METHODS: Systematic review of observational studies in which chronic traumatic brain injury was defined as any abnormality on clinical neurological examination, psychometric testing, neuroimaging studies, and electroencephalography. Studies were identified through database (1950 to date) and bibliographic searches without language restrictions. Two reviewers extracted study characteristics, quality, and data, with adherence to a protocol developed from a widely recommended method for systematic review of observational studies (MOOSE).

Results

36 papers had relevant extractable data (from a detailed evaluation of 93 studies of 943 identified from the initial search). Quality of evidence was generally poor. The best quality studies were those with a cohort design and those that used psychometric tests. These yielded the most negative results: only four of 17 (24%) better quality studies found any indication of chronic traumatic brain injury in a minority of boxers studied.

Conclusion

There is no strong evidence to associate chronic traumatic brain injury with amateur boxing.

SUBMITTER: Loosemore M

PROVIDER: S-EPMC2034739 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.

Loosemore Mike M Knowles Charles H CH Whyte Greg P GP

BMJ (Clinical research ed.) 20071004 7624

<h4>Objective</h4>To evaluate the risk of chronic traumatic brain injury from amateur boxing.<h4>Setting</h4>Secondary research performed by combination of sport physicians and clinical academics. DESIGN, DATA SOURCES, AND METHODS: Systematic review of observational studies in which chronic traumatic brain injury was defined as any abnormality on clinical neurological examination, psychometric testing, neuroimaging studies, and electroencephalography. Studies were identified through database (19 ...[more]

PMID: 17916811

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Project description:BackgroundIn traumatic brain injury (TBI), the appropriate timing and route of feeding, and the efficacy of immune-enhancing formulae have not been well established. We performed this meta-analysis aiming to compare the effects of different nutritional support modalities on clinical outcomes of TBI patients.MethodsWe systematically searched Pubmed, Embase, and the Cochrane Library until October, 2012. All randomized controlled trials (RCTs) and non-randomized prospective studies (NPSs) that compared the effects of different routes, timings, or formulae of feeding on outcomes in TBI patients were selected. The primary outcomes included mortality and poor outcome. The secondary outcomes included the length of hospital stay, the length of ventilation days, and the rate of infectious or feeding-related complications.Findings13 RCTs and 3 NPSs were included. The pooled data demonstrated that, compared with delayed feeding, early feeding was associated with a significant reduction in the rate of mortality (relative risk [RR]?=?0.35; 95% CI, 0.24-0.50), poor outcome (RR?=?0.70; 95% CI, 0.54-0.91), and infectious complications (RR?=?0.77; 95% CI, 0.59-0.99). Compared with enteral nutrition, parenteral nutrition showed a slight trend of reduction in the rate of mortality (RR?=?0.61; 95% CI, 0.34-1.09), poor outcome (RR?=?0.73; 95% CI, 0.51-1.04), and infectious complications (RR?=?0.89; 95% CI, 0.66-1.22), whereas without statistical significances. The immune-enhancing formula was associated with a significant reduction in infection rate compared with the standard formula (RR?=?0.54; 95% CI, 0.35-0.82). Small-bowel feeding was found to be with a decreasing rate of pneumonia compared with nasogastric feeding (RR?=?0.41; 95% CI, 0.22-0.76).ConclusionAfter TBI, early initiation of nutrition is recommended. It appears that parenteral nutrition is superior to enteral nutrition in improving outcomes. Our results lend support to the use of small-bowel feeding and immune-enhancing formulae in reducing infectious complications.

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Dataset Information

Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.

Objective

Setting

Results

Conclusion

Publications

Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies.

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